| Autor: |
Wenli Fang, Liyan Li, Zhongda Lin, Yuli Zhang, Zhangyan Jing, Yuan Li, Zhirang Zhang, Linlin Hou, Xin Liang, Xingding Zhang, Xudong Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Extracellular Vesicle, Vol 2, Iss , Pp 100021- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2773-0417 |
| DOI: |
10.1016/j.vesic.2022.100021 |
| Popis: |
Interleukin 15 (IL-15) is a pivotal immune cytokine that responses to cancer stress signals and maintains tissue-resident memory T (TRM) cells. It is therefore considered as a potent therapeutic immunomodulator agonist cancer. However, in addition to the aberrant expression of programmed cell death 1 ligand 1 (PD-L1), certain types of tumors lack surface expression of IL-15 and thereby leads to the deficiency of T cell-mediated anti-tumor response. Herein, we engineered cellular nanovesicles presenting IL-15/IL-15Rα (IL-15/IL-15Rα-NVs) complex. IL-15/IL-15Rα-NVs trans-present IL-15 to T cells and then boost the activation, proliferation and survival of tumor-infiltrated T cells to antagonize cancer cells. Small-molecule programmed cell death protein 1 (PD-1)/PD-L1 inhibitor 1 was loaded into the NVs and simultaneously prevented CD8+ T cell exhaustion mediated via PD-L1. Moreover, IL-15/IL-15Rα-NVs intensively evoked the activity and proliferation of CD8+ TRM cells, and could exert permanent anti-tumor response. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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