The listeriosis triangle: Pathogen, host and the environment
| Autor: | Abram Maja, Bubonja-Sonje Marina, Mihelcic Mirna, Vuckovic Darinka, Mustac Elvira |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Sanamed, Vol 7, Iss 1, Pp 37-42 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1452-662X 2217-8171 |
| Popis: | Listeria monocytogenes is a foodborne pathogen well known for its adaptability to diverse environment and host niches and its high fatality rate among infected immunocompromised populations. Infection in the immunocompetent host occurs but risk factors for the disease primarily points to abnormalities in cell-mediated and innate immunity as major predispositions to listeriosis. After ingestion of contaminated food, this pathogen is able to cross the intestinal, blood-brain and placental barrier and leads to gastroenteritis, meningitis and maternofetal infections which may result in abortion and spontaneous stillbirth. Despite the extensive use of this bacterium in the study of cell-mediated immunity and intracellular growth, our understanding of the host, pathogen and environmental factors that impact the pathogenesis of listeriosis is still incomplete. This review will summarize current knowledge, including our own efforts, about pathogen, host and environmental factors that influence, and contribute to the pathogenesis of Listeria monocytogenes infection. |
| Databáze: | Directory of Open Access Journals |
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