Toward the Production of Hydroxyapatite/Poly(Ether-Ether-Ketone) (PEEK) Biocomposites: Exploring the Physicochemical, Mechanical, Cytotoxic and Antimicrobial Properties

Autor: Meirilany Rozeno Costa, José Adeilton Carvalho Filho, Carlos Bruno Barreto Luna, Gleydis Manalig Pereira Dantas, Ana Cristina Figueiredo de Melo Costa, Nadja Maria da Silva Oliveira
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Polymers, Vol 16, Iss 17, p 2520 (2024)
Druh dokumentu: article
ISSN: 2073-4360
DOI: 10.3390/polym16172520
Popis: The development of hydroxyapatite (HAp) and polyether ether ketone (PEEK) biocomposites has been extensively studied for bone repair applications due to the synergistic properties of the involved materials. In this study, we aimed to develop HAp/PEEK biocomposites using high-energy ball milling, with HAp concentrations (20%, 40%, and 60% w/v) in PEEK, to evaluate their physicochemical, mechanical, cytotoxicity, and antimicrobial properties for potential applications in Tissue Engineering (TE). The biocomposites were characterized by structure, morphology, apparent porosity, diametral compression strength, cytotoxicity, and antimicrobial activity. The study results demonstrated that the HAp/PEEK biocomposites were successfully synthesized. The C2 biocomposite, containing 40% HAp, stood out due to the optimal distribution of HAp particles in the PEEK matrix, resulting in higher compression strength (246 MPa) and a homogeneous microstructure. It exhibited antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, with no cytotoxicity observed. These properties make the C2 biocomposite promising for regenerative medicine applications, combining mechanical strength, bioactivity, and biocompatibility.
Databáze: Directory of Open Access Journals
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