Pathological research on acute hepatic and renal tissue damage in Wistar rats induced by cocoa

Autor: Chiedozie Onyejiaka Ibegbulem, Paul Chidoka Chikezie, Ezeikel Chinemerem Dike
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Journal of Acute Disease, Vol 5, Iss 1, Pp 51-58 (2016)
Druh dokumentu: article
ISSN: 2221-6189
DOI: 10.1016/j.joad.2015.07.005
Popis: Objective: To ascertain the functional integrity of renal and hepatic tissues of Wistar rats fed with processed cocoa bean-based beverages and raw cocoa bean products-containing diets by using biochemical and histological methods. Methods: Thirty Wistar rats were designated on the basis of experimental diets which were given for 28 days. At the end of the feeding period, blood samples were drawn, and renal and hepatic tissues were excised from the experimental rat groups for functional tests and histological examinations, respectively. Results: Serum alanine aminotransferase activities of the experimental rat groups showed no significant difference (P > 0.05) and were within a relatively narrow range of (32.17 ± 4.98) IU/L to (41.00 ± 10.85) IU/L, whereas serum aspartate aminotransferase activities gave wide variation within the range of (15.67 ± 2.13) IU/L to (34.83 ± 8.31) IU/L with P
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