Assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro-2a neuroblastoma cell lines
| Autor: | Gabriela García-Cerón, Alba Fernanda Solano-González, Iván Hazael Bello-Cortés, Ileana Andrea Bonilla-Brunner, Daniela Araiza-Olivera, Manuel Gutiérrez-Aguilar, Yazmin Ramiro-Cortés, Marcos Francisco Rosetti, Roeb García-Arrazola |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | All Life, Vol 17, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2689-5307 26895293 |
| DOI: | 10.1080/26895293.2024.2407213 |
| Popis: | In the present study, in vitro neuronal cell cultures were exposed to the two most common varieties of EDCs reported in food, phthalates and bisphenol A (BPA). Specifically, Bis (2-ethylhexyl) phthalate (DEHP), Mono-butyl-phthalate (MBP), Di-n-octylphthalate (OP), and Bisphenol A (BPA) were exposed in Neuro-2a neuroblastoma cell line. The enzymatic activity of methionine synthase (MS) was reduced by up to 3-fold in comparison to cultures that were not exposed to EDCs. MS is the key enzyme in the metabolic pathway that has been proposed elsewhere to be related to redox/methylation related disorders. |
| Databáze: | Directory of Open Access Journals |
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