Effect of 3-4,methylenedioxymethamphetamine in CA1 hippocampal neurons in male Rats
| Autor: | Soleimani Asl S, Shekarriz N, Molavi N, Basirat A, Falahati P, Esmaeili F, Azimi Z, Sajadi F, Mehdizadeh M |
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| Jazyk: | perština |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | مجله دانشگاه علوم پزشکی گرگان, Vol 15, Iss 1, Pp 31-37 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1562-4765 2008-4080 |
| Popis: | Background and Objective: Considering the role of the hippocampus in memory, this study was done to evaluate the effect of 3-4,methylenedioxymethamphetamine on CA1 hippocampal neurons in male rats. Materials and Methods: In this experimental study 18 sprague dawley male rats (200-250g) were randomly allocated into three groups as follow: control (intact), control sham and experimental groups. Sham and experimental groups were received normal salin (1 cc) and MDMA10mg/kg IP for 7 days, respectively. Following transcardial perfusion by paraformaldehid 4%, structure and ultrastructure of right CA1 hippocampus were assessed by crysel violet staining and electronic microscope. Data were analyzed using SPSS-16, ANOVA and Tukey tests. Results: There was no significant difference between control (mean=210±40.38) and sham groups (mean=199±38.7) in neuron density. Neuron number decreased significantly in experimental group (mean=98±25.4) in compare to control and sham groups (P |
| Databáze: | Directory of Open Access Journals |
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