The therapeutic effect of ingestion of shark cartilage (Carcharhinuss dussumieri) on the growth of Dimethylbenzanthracene induced mammary tumor in Sprague Dawley rat
| Autor: | Nematollah Razmi, Hamid Kolalian Moghadam, Mohammad Reza Tabandeh, Abolfazl Babakhani |
|---|---|
| Jazyk: | English<br />Persian |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Iranian South Medical Journal, Vol 10, Iss 2, Pp 104-111 (2008) |
| Druh dokumentu: | article |
| ISSN: | 1735-4374 1735-6954 73294268 |
| Popis: | Background: Recently, ingestion of shark cartilage has been increased among patients with cancer on the basis of this claim that sharks rarely develop cancer because of their high proportion of cartilage and antiangiogenesis compounds. The goal of this study was to evaluate the antitumor effect of shark cartilage and growth of induced mammary tumors in rat using dimethylbenzanthracene (DMBA) and to assess the improvement in some Quality-of-Life markers. Methods: Tumors were induced by 7, 12 Dimethylbenzanthracene (DMBA) 20mg/2ml corn oil for each rat using gavage method. Cartilage powder was prepared from neural cord of white snout shark (Persian Gulf, Iran).A total of 60 Sprague Dawley rats were divided in two groups (30 rats in each group): pretumor establishment treatment (PRTE) and post tumor establishment treatment (PSTE). Each group was divided in two control (n=15) and treatment (n=15) subgroups. Animals in treatment PRTE (30 days after tumor induction) and PSTE (after palpable tumors were established) groups were treated with 10mg/day /rat shark cartilage for 30 days. Animal weight gaining, tumor induction time, tumor number and size were recorded on induction and 30, 60, 120 and 200 days after induction. Results: There was no significant difference in number and size of tumors between PSTE treatment and PRTE control, two months after treatment (P>0.05), but this difference was significant between PSTE treatment and PSTE control groups (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|