Bone metabolism dynamics in the early post-transplant period following kidney and liver transplantation.

Autor: Peter W Schreiber, Heike A Bischoff-Ferrari, Katia Boggian, Marco Bonani, Christian van Delden, Natalia Enriquez, Thomas Fehr, Christian Garzoni, Hans H Hirsch, Cédric Hirzel, Oriol Manuel, Pascal Meylan, Lanja Saleh, Maja Weisser, Nicolas J Mueller, Swiss Transplant Cohort Study (STCS)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: PLoS ONE, Vol 13, Iss 1, p e0191167 (2018)
Druh dokumentu: article
ISSN: 1932-6203
73248150
DOI: 10.1371/journal.pone.0191167
Popis: Bone disease contributes to relevant morbidity after solid organ transplantation. Vitamin D has a crucial role for bone metabolism. Activation of vitamin D depends on the endocrine function of both, liver and kidney. Our study assessed key markers of bone metabolism at time of transplantation and 6 months after transplantation among 70 kidney and 70 liver recipients. In 70 kidney recipients 25-OH vitamin D levels did not differ significantly between peri-transplant (median 32.5nmol/l) and 6 months post-transplant (median 41.9nmol/l; P = 0.272). Six months post-transplant median 1, 25-(OH)2 vitamin D levels increased by >300% (from 9.1 to 36.5ng/l; P
Databáze: Directory of Open Access Journals
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