HPLC-MS method development and validation for simultaneous quantitation of GZK-111 and CPG compounds in rat plasma

Autor:	A. L. Podolko, P. O. Bochkov, G. B. Kolyvanov, A. A. Litvin, O. G. Gribakina, R. V. Shevchenko, V. P. Zherdev
Jazyk:	ruština
Rok vydání:	2020
Předmět:	gzk-111 cpg quantitative determination high-performance liquid chromatography-mass-spectrometry blood plasma Pharmacy and materia medica RS1-441
Zdroj:	Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 28-36 (2020)
Druh dokumentu:	article
ISSN:	2587-7836 2686-8830
DOI:	10.37489/2587-7836-2019-4-28-36
Popis:	The technique of quantitative determination of GZK-111 and CPG compounds in rat blood plasma has been developed. The analysis was carried out using the combined method of high-performance liquid chromatography with mass spectrometric detection. The method was linear in the concentration range of 25-1000 ng/ml for both compounds. Percentage of GZK-111 extraction from rat blood plasma was 57.8 %. The lower limit of detection for GZK- 111 compound was 25 ng/ml. Percentage of extraction of CPG compound was 42.5 %. The lower limit of detection of CPG compound was also 25 ng/ml.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e7320be9da7d4599ac49f9cdb22d86c3 Zobrazit plný text záznamu View record in DOAJ