Carboxybetaine and Carboxybetaine Ester Derivatives of Tetra(dodecyloxyphenyl)-calix[4]resorcinarene: Synthesis, Self-Assembly and In Vitro Toxicity

Autor:	Julia E. Morozova, Zuchra R. Gilmullina, Victor V. Syakaev, Alexandra D. Voloshina, Anna P. Lyubina, Syumbelya K. Amerhanova, Olga B. Babaeva, Vasily M. Babaev, Igor S. Antipin
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	calix[4]resorcinarene carboxybetaine hemolytic activity cytotoxicity Inorganic chemistry QD146-197
Zdroj:	Molbank, Vol 2023, Iss 1, p M1562 (2023)
Druh dokumentu:	article
ISSN:	1422-8599
DOI:	10.3390/M1562
Popis:	Amphiphilic calix[4]resorcinarenes are a class of macrocyclic compounds with broad potential utility including nanomedicine. Here the synthesis of new carboxybetaine and carboxybetaine ester calix[4]resorcinarene bearing 4-(dodecyloxy)phenyl groups on the lower rim is presented. The compounds were characterized by 1H-NMR, 13C-NMR, 2D NMR, IR, ESI and elemental analysis. The critical association concentration values are 1.00 × 10−5 and 1.18 × 10−5 mol·L−1 for carboxybetain and ester, respectively. The hemolytic activity of the macrocycles and their cytotoxicity against normal (WI-38, Chang liver) and tumor cells (M-HeLa) are also estimated.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/731f4594c9cf4856a90f3064a54d606e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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