Autor: |
Julia E. Morozova, Zuchra R. Gilmullina, Victor V. Syakaev, Alexandra D. Voloshina, Anna P. Lyubina, Syumbelya K. Amerhanova, Olga B. Babaeva, Vasily M. Babaev, Igor S. Antipin |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Molbank, Vol 2023, Iss 1, p M1562 (2023) |
Druh dokumentu: |
article |
ISSN: |
1422-8599 |
DOI: |
10.3390/M1562 |
Popis: |
Amphiphilic calix[4]resorcinarenes are a class of macrocyclic compounds with broad potential utility including nanomedicine. Here the synthesis of new carboxybetaine and carboxybetaine ester calix[4]resorcinarene bearing 4-(dodecyloxy)phenyl groups on the lower rim is presented. The compounds were characterized by 1H-NMR, 13C-NMR, 2D NMR, IR, ESI and elemental analysis. The critical association concentration values are 1.00 × 10−5 and 1.18 × 10−5 mol·L−1 for carboxybetain and ester, respectively. The hemolytic activity of the macrocycles and their cytotoxicity against normal (WI-38, Chang liver) and tumor cells (M-HeLa) are also estimated. |
Databáze: |
Directory of Open Access Journals |
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