Monitoring levodopa oxidation and reduction reactions using surface plasmon resonance on a nanohole array electrode

Autor: Hao-Fang Peng, Chih-Kang Chang, Rohit Gupta, Jian-Jang Huang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Discover Nano, Vol 18, Iss 1, Pp 1-9 (2023)
Druh dokumentu: article
ISSN: 2731-9229
84559950
DOI: 10.1186/s11671-023-03930-5
Popis: Abstract The traditional method of monitoring the oxidation and reduction of biomedical materials usually relies on electrochemical (EC) measurement techniques. Here, we demonstrate a surface plasmon resonance (SPR) method to monitor the oxidation process. Using levodopa L-dopa as the target analyte, a nanohole sensing plate is embedded in the EC electrode to enhance the oxidation signal and generate SPR. Cyclic voltammetry (CV) measurement was first conducted to understand the baseline of EC response of L-Dopa. Then, the redox reactions were simultaneously monitored through SPR measurements during the CV voltage scan. The results showed that the limit of detection using traditional CV reached 1.47 μM while using EC-SPR, the limit of detection improved to 1.23 μM. Most importantly, we found a strong correlation between CV current profiles and the SPR reflection spectra. Our results facilitate detecting electrochemical reactions using an optical probing method.
Databáze: Directory of Open Access Journals
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