Higher systolic blood pressure is specifically associated with better islet beta-cell function in T2DM patients with high glycemic level

Autor: Zhang Xia, Lijuan Song, Dongdong Fang, Wenjun You, Feng Li, Deqiang Zheng, Yuhao Li, Lu Lin, Jingtao Dou, Xin Su, Qi Zhai, Yingting Zuo, Yibo Zhang, Herbert Y. Gaisano, Jiajia Jiang, Yan He
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-10 (2022)
Druh dokumentu: article
ISSN: 1475-2840
DOI: 10.1186/s12933-022-01723-1
Popis: Abstract Background Patients with type 2 diabetes mellitus (T2DM) usually have higher blood viscosity attributed to high blood glucose that can decrease blood supply to the pancreas. A mild increase in blood pressure (BP) has been reported as a potential compensatory response that can maintain blood perfusion in the islet. However, how BP influences beta-cell function in T2DM subjects remains inconsistent. This study aimed to examine the relationship between BP and beta-cell function in patients with T2DM under different HbA1c levels. Methods This is a cross-sectional study of 615 T2DM patients, whose clinical data were extracted from hospital medical records. Beta-cell function was assessed by insulin secretion-sensitivity index-2 (ISSI2). Multivariable linear regression analysis and restricted cubic splines (RCS) analysis were performed to identify the association between systolic BP (SBP) and ISSI2. Mediation analysis was performed to determine whether higher SBP could reduce blood glucose by enhancing beta-cell function. Results After adjustment of potential confounders, in participants with HbA1c ≥ 10%, the SBP between 140 to150 mmHg had the highest log ISSI2 (b = 0.227, 95% CI 0.053–0.402), an association specific to participants with
Databáze: Directory of Open Access Journals
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