Epidemiology of Pertussis and Pertussis-Related Complications in Adults: A German Claims Data Analysis

Autor: Bastian Surmann, Julian Witte, Manuel Batram, Carl Peter Criée, Christiane Hermann, Andreas Leischker, Jörg Schelling, Mirko Steinmüller, Klaus Wahle, Alexander F. Heiseke, Pavo Marijic
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Infectious Diseases and Therapy, Vol 13, Iss 2, Pp 385-399 (2024)
Druh dokumentu: article
ISSN: 2193-8229
2193-6382
DOI: 10.1007/s40121-023-00912-z
Popis: Abstract Introduction Pertussis is a highly contagious respiratory infection. It affects people of all ages, yet evidence of the impact of pertussis in adults with underlying conditions (UCs) is scarce. This study investigated the incidence and complication rate of pertussis in adult patients with and without UC. Methods A retrospective analysis was conducted using routinely collected German claims data between 2015 and 2019. Patients with and without different pneumological, cardiovascular, endocrinological, musculoskeletal, and psychological UCs were matched for incidence estimation. Logistic regression models were used to estimate the risk of pertussis depending on the presence of UCs. Negative binomial models were used to assess complication rates in patients with pertussis and with and without UC. Results In total, 4383 patients were diagnosed with pertussis during the study period. Patients with any UC had an increased risk for pertussis compared to matched patients without UC (odds ratio [OR] 1.72; 95% confidence interval [CI]1.60–1.84, p
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