| Autor: |
Jea-Young Lee, Zhen-Jie Wang, Alexa Moscatello, Chase Kingsbury, Blaise Cozene, Jeffrey Farooq, Madeline Saft, Nadia Sadanandan, Bella Gonzales-Portillo, Henry Zhang, Felipe Esparza Salazar, Alma Rosa Lezama Toledo, Germán Rivera Monroy, Reed Berlet, Cyndy D. Sanberg, Paul R. Sanberg, Cesario V. Borlongan |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2058-7716 |
| DOI: |
10.1038/s41420-022-01175-2 |
| Popis: |
Gut-Brain Axis as a PD Pathologic Source and Therapeutic Target. The PD murine model of α-synuclein overexpression at around 8 weeks of age manifests gut dysbiosis, characterized by inflammation-specific microbiota and cytokines, which can trigger brain neurodegeneration, especially dopaminergic depletion reminiscent of PD pathology. Targeting the dysbiotic gut via intravenous hUCB stem cell transplantation can render gut homeostasis and sequester peripheral as well as central inflammation, leading to brain repair and amelioration of PD behavioral and histological deficits. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink