| Autor: |
Styliani Parpoudi, Ioannis Mantzoros, Anna Gkiouliava, Dimitrios Kyziridis, Apostolos Makrantonakis, Christos Chatzakis, Christos Gekas, Dimitrios Konstantaras, Orestis Ioannidis, Stefanos Bitsianis, Dimosthenis Miliaras, Stamatios Aggelopoulos |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Asian Journal of Surgery, Vol 45, Iss 11, Pp 2191-2196 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1015-9584 |
| DOI: |
10.1016/j.asjsur.2021.11.001 |
| Popis: |
Background: The use of prosthetic meshes in abdominal wall reconstruction is a well-established approach; however, in certain cases where a bowel resection coexists its application is disputed. Any underlying inflammatory process may augment adhesion formation which is a major postoperative complication. In this animal study, our aim was to investigate the effect of N-acetyl-l-cysteine (NAC) on adhesion formation and the expression of inflammatory markers when a mesh was used in a clean or a potentially contaminated environment. Methods: Sixty male Wistar rats were randomly and equally allocated in 3 groups: A, B and C. Animals in all groups underwent laparotomy, a prosthetic mesh was placed and chemoprophylaxis with ciprofloxacin was administered. In groups B and C an enterectomy was also performed. NAC was injected intraperitoneally in group C. Adhesion formation, IL-1a, IL-6, TNF-a and histological data including fibrosis, neutrophils’ infiltration and neovascularization were assessed. Mesh samples were sent for cultivation. Results: Adhesion formation was significantly less and inflammation markers were also lower in group C compared to group B (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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