Association of TCF7L2 rs7903146 Polymorphism with Diabetic Nephropathy in Type 2 Diabetes Mellitus Egyptian Patients
| Autor: | Abdelrahman Rabia Ali, Alaa Mohamed Rabea, Shimaa Ali Abdelkareem, Rania Elsayed Sheir |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Egyptian Journal of Medical Research, Vol 2, Iss 2, Pp 7-19 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2682-4396 2682-440X |
| DOI: | 10.21608/ejmr.2021.174195 |
| Popis: | Background: Transcription factor 7-like 2 (TCF7L2) gene polymorphisms are known risk factors for type 2 diabetes mellitus (T2DM). However, the relationship between TCF7L2 polymorphism and diabetic nephropathy (DN) is inconclusive. Objectives: to explore the association of TCF7L2 rs7903146 (C/T) gene polymorphism and DN in T2DM Egyptian patients. Methods: 80 patients with T2DM (40 patients without DN and 40 patients with DN) were enrolled in the study. Genotyping for the rs7903146 (C/T) polymorphism in TCF7L2 gene was performed by real time PCR. Results: The frequency of rs7903146 genotypes in diabetic patients without DN was ( CC: 57.5%; CT: 37.5%; TT: 5%), while in diabetic patients with DN was (CC: 2.5%; CT: 40%; TT: 57.5%). Patients with DN were exposed to the TT 25.7 times more than who didn’t develop DN (OR= 25.7, 95% CI= 0.43-94, P= 0.001**). Upon examining the allelic discrimination, C allele was present in 77.5% of patients without DN versus 23.8% of patients with DN, While T allele was found in 22.5% of patients without DN versus 76.3% of patients with DN. Patients with DN were exposed to the T allele 11 times more than who didn’t develop nephropathy (OR=11, 95% CI= 5.3-23.1 , P= |
| Databáze: | Directory of Open Access Journals |
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