Antithrombotic Activity of an Indolinone Derivative – a Soluble Guanylate Cyclase Stimulator
| Autor: | V. V. Bykov, A. V. Bykova, V. I. Smolyakova, G. A. Chernysheva, O. I. Alyev, A. M. Anishenko, A. V. Sidekhmenova, S. A. Stankevich, V. A. Khazanov, A. I. Vengerovsky |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Разработка и регистрация лекарственных средств, Vol 11, Iss 3, Pp 70-74 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2305-2066 2658-5049 |
| DOI: | 10.33380/2305-2066-2022-11-3-70-74 |
| Popis: | Introduction. The article presents the results of studying the antithrombotic activity of a novel drug, a soluble guanylate cyclase stimulator (codename – GRS), in experimental models of arterial and venous thrombosis and thromboembolism.Aim. Study the antithrombotic action of GRS compound in comparison with clopidogrel and rivaroxaban in the following models: arterial thrombosis induced by iron chloride application to carotid artery wall in rats; thromboembolism induced by intravenous administration of thrombin solution in mice; venous thrombosis induced by the ligature of inferior vena cava in rats.Materials and methods. Arterial thrombosis was modelled in rats by applying a pad soaked in iron chloride (FeCl3) to the carotid artery, GRS compound was administered orally in median effective dose of 10 mg/kg once 3 hours before pad application. Blood flow in carotid arteries and blood clot mass were registered. Thromboembolism was induced in mice by intravenous administration of thrombin solution, GRS in dose 10 mg/kg or the reference drug clopidogrel were administered once orally daily for 3 days. Animal mortality, survival time and blood clot size were registered. Venous thrombosis was induced in rats by the ligature of inferior vena cava below renal veins, GRS in dose 10 mg/kg, reference drug rivaroxaban in 5 mg/kg dose or their combination in these doses were administered once orally 1 hour before vein ligature. The mass of dry and wet blood clots was registered.Results and discussion. In arterial thrombosis model GRS compound in 10 mg/kg, administered 3 hours before iron chloride application, increased the time to blood flow cessation in the carotid artery by 35 % and reduced the frequency of complete artery occlusion by 2 times compared to the control group (р |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|