| Autor: |
Jason Neidleman, Xiaoyu Luo, Julie Frouard, Guorui Xie, Gurjot Gill, Ellen S. Stein, Matthew McGregor, Tongcui Ma, Ashley F. George, Astrid Kosters, Warner C. Greene, Joshua Vasquez, Eliver Ghosn, Sulggi Lee, Nadia R. Roan |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Cell Reports Medicine, Vol 1, Iss 6, Pp 100081- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2666-3791 |
| DOI: |
10.1016/j.xcrm.2020.100081 |
| Popis: |
Summary: Convalescing coronavirus disease 2019 (COVID-19) patients mount robust T cell responses against SARS-CoV-2, suggesting an important role of T cells in viral clearance. To date, the phenotypes of SARS-CoV-2-specific T cells remain poorly defined. Using 38-parameter CyTOF, we phenotyped longitudinal specimens of SARS-CoV-2-specific CD4+ and CD8+ T cells from nine individuals who recovered from mild COVID-19. SARS-CoV-2-specific CD4+ T cells were exclusively Th1 cells and predominantly Tcm cells with phenotypic features of robust helper function. SARS-CoV-2-specific CD8+ T cells were predominantly Temra cells in a state of less terminal differentiation than most Temra cells. Subsets of SARS-CoV-2-specific T cells express CD127, can proliferate homeostatically, and can persist for over 2 months. Our results suggest that long-lived and robust T cell immunity is generated following natural SARS-CoV-2 infection and support an important role of SARS-CoV-2-specific T cells in host control of COVID-19. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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