Primary postpartum hemorrhage in women with von Willebrand disease and carriers of hemophilia: a retrospective analysis

Autor: Marieke Punt, Fe van Leusden, Kitty Bloemenkamp, Michiel Coppens, Mariette Driessens, Floor Heubel-Moenen, Titia Lely, Anja Mäkelburg, Laurens Nieuwenhuizen, Saskia Haitjema, Wouter van Solinge, Joline Saes, Saskia Schols, Roger Schutgens, Jeroen Eikenboom, Marieke Kruip, Karin van Galen
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 5, Pp 102508- (2024)
Druh dokumentu: article
ISSN: 2475-0379
DOI: 10.1016/j.rpth.2024.102508
Popis: Background: Between 2002 and 2011, the incidence of severe primary postpartum hemorrhage (PPH) in Dutch women with von Willebrand disease (VWD) and hemophilia carriers (HCs) was 8% vs 4.5% in the general population. Objectives: To determine the contemporary incidence of severe primary PPH in women with VWD and HCs. Methods: All women with VWD or HCs who delivered between 2012 and 2017 were selected from all 6 Dutch hemophilia treatment centers. Data on patient and disease characteristics, peripartum hematologic and obstetric management, and outcomes were retrospectively collected. Incidence of severe primary (≥1000 mL of blood loss ≤24 hours after childbirth) and primary (≥500 mL within ≤24 hours after childbirth) PPH was compared with the (1) previous cohort and (2) general Dutch population and between (3) women with VWD and HCs with third-trimester coagulation activity levels
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