| Autor: |
Ditte Buchwald, Casper Schmidt, Dorte Buchwald, Kristina Iris Winter, Ivan Bo Nielsen, Kirsten Klostergaard, Dorte Melgaard, Steen K. Fagerberg, Peter Derek Christian Leutscher |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Palliative Medicine Reports, Vol 4, Iss 1, Pp 326-333 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2689-2820 |
| DOI: |
10.1089/PMR.2023.0024 |
| Popis: |
Background: Cannabis may offer therapeutic benefits to patients with advanced cancer not responding adequately to conventional palliative treatment. However, tolerability is a major concern. Cognitive function is a potential adverse reaction to tetrahydrocannabinol containing regimens. The aim of this study was to test cognitive function in patients being prescribed dronabinol as an adjuvant palliative therapy. Methods: Adult patients with advanced cancer and severe related pain refractory to conventional palliative treatment were included in this case-series study. Patients were examined at baseline in conjunction with initiation of dronabinol therapy and at a two-week follow-up using three selected Wechsler's adult intelligence scale III neurocognitive tests: Processing Speed Index (PSI), Perceptual Organization Index (POI), and Working Memory Index (WMI). Patients were also assessed using pain visual analog scale, Major Depression Inventory, and Brief Fatigue Inventory. Results: Eight patients consented to take part in the study. Two patients discontinued dronabinol therapy, one due to a complaint of dizziness and another critical progression of cancer disease, respectively. The remaining six patients were successfully treated with a daily dosage of 12.5?mg dronabinol (p?=?0.039). PSI (p?=?0.020), POI (p?=?0.034.), and WMI (p?=?0.039). Conclusions: Cognitive function improved in this group of patients with advanced cancer in conjunction with low-dose dronabinol therapy. The cause is likely multifactorial including reported relief of cancer-associated symptoms. Further clinical investigation is required. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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