Screening for oncogenic AF1q expression predicts disease recurrence in gastric cancer patients

Autor: Elisabeth S. Gruber, Georg Oberhuber, Michaela Schlederer, Peter Birner, Gerd Jomrich, Sebastian F. Schoppmann, William Tse, Lukas Kenner
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-024-67058-x
Popis: Abstract AF1q associates with tumor progression and metastases upon WNT signaling. The downstream WNT target CD44 has demonstrated prognostic significance in gastric cancer (GC). This study evaluates the impact of AF1q on tumor stage and survival in GC patients. Immunohistochemical marker expression was analyzed and data were processed to correlation and survival analysis. Out of 182 GC samples, 178 (97.8%) showed moderate to high AF1q expression (p
Databáze: Directory of Open Access Journals
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