Central obesity and fat-free mass are associated with a larger spleen volume in the general population

Autor: Mohammed Farah Mahmoud Mousa, Muhammad Naeem, Saima Bibi, Robin Bülow, Martin Bahls, Ulrike Siewert-Markus, Philipp Töpfer, Ali Aghdassi, Muhammad Nasir Khan Khattak, Henry Völzke, Marcello RP Markus, Till Ittermann
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Upsala Journal of Medical Sciences, Vol 129, Pp 1-8 (2024)
Druh dokumentu: article
ISSN: 0300-9734
2000-1967
DOI: 10.48101/ujms.v129.10465
Popis: Background and aim: As the spleen plays a significant role in immunity, the aim was to investigate the associations of different body composition markers derived from various sources with spleen volume in a general population sample. Materials and methods: Cross-sectional data of 1095 individuals (570 women; 52%) aged between 30 and 90 years were collected in the Study of Health in Pomerania (SHIP-START-2). We measured spleen volume by magnetic resonance imaging (MRI).Body composition markers were derived from classic anthropometry, bioelectrical impedance analysis, including absolute fat mass (FM) and fat-free mass (FFM), as well as from MRI, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and liver fat content. Sex-stratified-adjusted linear regression models were used to analyze the associations of body composition markers with spleen volumes. Results: We observed positive associations of body mass index, body weight, waist circumference, hip circumference, waist-to-height ratio, absolute FM, absolute FFM, and VAT and SAT with spleen volume in men and women. An 8.12 kg higher absolute FFM was associated with a 38.4 mL (95% confidence interval [CI]: 26.7–50.1) higher spleen volume in men and a 5.21 kg higher absolute FFM with a 42.6 mL (95% CI: 26.2–59.0) higher spleen volume in women. Conclusion: Our findings indicate that obesity-related body composition markers and FFM are associated with a higher spleen volume. Particularly, higher absolute FFM showed a strong association with a larger spleen volume in both men and women. Further studies are warranted to understand the clinical significance of body composition markers on large spleen volume.
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