In Silico Analysis of Nanoplastics’ and β-amyloid Fibrils’ Interactions

Autor: Silvia Gabbrielli, Luca Colnaghi, Gemma Mazzuoli-Weber, Alberto Cesare Luigi Redaelli, Alfonso Gautieri
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Molecules, Vol 28, Iss 1, p 388 (2023)
Druh dokumentu: article
ISSN: 28010388
1420-3049
DOI: 10.3390/molecules28010388
Popis: Plastic pollution has become a global environmental threat, which leads to an increasing concern over the consequences of plastic exposition on global health. Plastic nanoparticles have been shown to influence the folding of proteins and influence the formation of aberrant amyloid proteins, therefore potentially triggering the development of systemic and local amyloidosis. This work aims to study the interaction between nanoplastics and β-amyloid fibrils to better understand the potential role of nanoplastics in the outbreak of neurodegenerative disorders. Using microsecond-long coarse-grained molecular dynamics simulations, we investigated the interactions between neutral and charged nanoparticles made of the most common plastic materials (i.e., polyethylene, polypropylene, and polystyrene) and β-amyloid fibrils. We observe that the occurrence of contacts, region of amyloid fibril involved, and specific amino acids mediating the interaction depend on the type and charge of the nanoparticles.
Databáze: Directory of Open Access Journals
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