| Autor: |
Lena Mungenast, Ronya Nieminen, Carine Gaiser, Ana Bela Faia-Torres, Jürgen Rühe, Laura Suter-Dick |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Biomaterials and Biosystems, Vol 11, Iss , Pp 100081- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2666-5344 |
| DOI: |
10.1016/j.bbiosy.2023.100081 |
| Popis: |
Traumatic injury to the spinal cord (SCI) causes the transection of neurons, formation of a lesion cavity, and remodeling of the microenvironment by excessive extracellular matrix (ECM) deposition and scar formation leading to a regeneration-prohibiting environment. Electrospun fiber scaffolds have been shown to simulate the ECM and increase neural alignment and neurite outgrowth contributing to a growth-permissive matrix. In this work, electrospun ECM-like fibers providing biochemical and topological cues are implemented into a scaffold to represent an oriented biomaterial suitable for the alignment and migration of neural cells in order to improve spinal cord regeneration. The successfully decellularized spinal cord ECM (dECM), with no visible cell nuclei and dsDNA content |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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