Human leukocyte antigen susceptibility genes in multiple sclerosis

Autor: Wei QIU, Xue⁃qiang HU
Jazyk: English<br />Chinese
Rok vydání: 2012
Předmět:
Zdroj: Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 12, Iss 2, Pp 127-130 (2012)
Druh dokumentu: article
ISSN: 1672-6731
Popis: Multiple sclerosis (MS) is an immune ⁃ related demyelinating disease of the central nervous system. The onset age of MS is usually between 20-40 years, showing a heterogeneous clinical feature. Due to the high disability rate, MS causes a huge burden to the society. MS is a complex disease caused by the genetic and environmental factors, in which genetic factors play a critical role. HLA gene complex is the most important determinant in MS risk, with a risk factor rate more than 60%. HLA gene complex has been a focus in MS research worldwide. DOI:10.3969/j.issn.1672⁃6731.2012.02.006
Databáze: Directory of Open Access Journals