Doença de Kikuchi-Fujimoto Kikuchi-Fujimoto disease

Autor:	Rogério Gastal Xavier, Denise Rossato Silva, Mauro Waldemar Keiserman, Maria Francisca Torres Lopes
Jazyk:	English<br />Portuguese
Rok vydání:	2008
Předmět:	Febre Linfonodos Doenças raras Tuberculose dos linfonodos Linfadenite histiocítica necrosante Lúpus eritematoso sistêmico Fever Lymph nodes Rare diseases Tuberculosis lymph node Histiocytic necrotizing lymphadenitis Lupus erythematosus systemic Diseases of the respiratory system RC705-779
Zdroj:	Jornal Brasileiro de Pneumologia, Vol 34, Iss 12, Pp 1074-1078 (2008)
Druh dokumentu:	article
ISSN:	1806-3713 1806-3756
DOI:	10.1590/S1806-37132008001200014
Popis:	A doença de Kikuchi-Fujimoto é caracterizada por febre e linfadenopatia, geralmente cervical. Esta doença acomete principalmente mulheres jovens. Pode ser confundida com linfoma, metástase de adenocarcinoma e tuberculose. Relatamos dois casos da doença de Kikuchi-Fujimoto. No primeiro caso, uma paciente de 28 anos havia tratado tuberculose há um ano e apresentava quadro clínico e histológico compatível com a doença de Kikuchi-Fujimoto. A segunda paciente, de 58 anos, recebeu tratamento inicialmente para granulomatose de Wegener e, posteriormente, para tuberculose. O exame histopatológico com estudo imunohistoquímico permitiu estabelecer o diagnóstico da doença de Kikuchi-Fujimoto nos dois casos. Após o diagnóstico definitivo, ambas foram tratadas sintomaticamente e melhoraram clinicamente dentro de um mês. Posteriormente, a segunda paciente desenvolveu lúpus eritematoso sistêmico.Kikuchi-Fujimoto disease is characterized by fever and lymphadenopathy, usually localized in the cervical region. This disease principally affects young females. It can be confused with lymphoma, adenocarcinoma metastasis and tuberculosis. We report two cases of Kikuchi-Fujimoto disease. In the first case, a 28-year-old female had been treated for tuberculosis one year prior and presented with a clinical and histological profile compatible with Kikuchi-Fujimoto disease. The second patient, a 58-year-old female, initially received treatment for Wegener's granulomatosis and, subsequently, for tuberculosis. Histopathological examination followed by immunohistochemical analysis confirmed the diagnosis of Kikuchi-Fujimoto disease in both cases. After the definitive diagnosis had been made, both patients were treated symptomatically, and both presented clinical improvement within one month. Subsequently, the latter patient developed systemic lupus erythematosus.
Databáze:	Directory of Open Access Journals
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