| Autor: |
Henry Ddumba Mawejje, David Weetman, Adrienne Epstein, Amy Lynd, Jimmy Opigo, Catherine Maiteki-Sebuguzi, Jo Lines, Moses R. Kamya, Philip J. Rosenthal, Martin J. Donnelly, Grant Dorsey, Sarah G. Staedke |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Current Research in Parasitology and Vector-Borne Diseases, Vol 3, Iss , Pp 100106- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2667-114X |
| DOI: |
10.1016/j.crpvbd.2022.100106 |
| Popis: |
Insecticide resistance threatens recent progress on malaria control in Africa. To characterize pyrethroid resistance in Uganda, Anopheles gambiae (s.s.) and Anopheles arabiensis were analyzed from 11 sites with varied vector control strategies. Mosquito larvae were collected between May 2018 and December 2020. Sites were categorized as receiving no indoor-residual spraying (‘no IRS’, n = 3); where IRS was delivered from 2009 to 2014 and in 2017 and then discontinued (‘IRS stopped’, n = 4); and where IRS had been sustained since 2014 (‘IRS active’, n = 4). IRS included bendiocarb, pirimiphos methyl and clothianidin. All sites received long-lasting insecticidal nets (LLINs) in 2017. Adult mosquitoes were exposed to pyrethroids; with or without piperonyl butoxide (PBO). Anopheles gambiae (s.s.) and An. arabiensis were identified using PCR. Anopheles gambiae (s.s.) were genotyped for Vgsc-995S/F, Cyp6aa1, Cyp6p4-I236M, ZZB-TE, Cyp4j5-L43F and Coeae1d, while An. arabiensis were examined for Vgsc-1014S/F. Overall, 2753 An. gambiae (s.l.), including 1105 An. gambiae (s.s.) and 1648 An. arabiensis were evaluated. Species composition varied by site; only nine An. gambiae (s.s.) were collected from ‘IRS active’ sites, precluding species-specific comparisons. Overall, mortality following exposure to permethrin and deltamethrin was 18.8% (148/788) in An. gambiae (s.s.) and 74.6% (912/1222) in An. arabiensis. Mortality was significantly lower in An. gambiae (s.s.) than in An. arabiensis in ‘no IRS’ sites (permethrin: 16.1 vs 67.7%, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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