Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types

Autor: Jasneet Kaur Khalsa, Nina Cheng, Joshua Keegan, Ameen Chaudry, Joseph Driver, Wenya Linda Bi, James Lederer, Khalid Shah
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-17704-5
Popis: Syngeneic mouse models for glioblastoma (GBM) cannot fully recapitulate clinical findings and response to therapy in patients. Here the authors perform a comprehensive immune profiling of different syngeneic GBM tumour models and compare it with the immune landscape of GBM patients to identify similarities and potential confounding differences.
Databáze: Directory of Open Access Journals