| Autor: |
Till F M Andlauer, Sabrina Scholz-Kornehl, Rui Tian, Marieluise Kirchner, Husam A Babikir, Harald Depner, Bernhard Loll, Christine Quentin, Varun K Gupta, Matthew G Holt, Shubham Dipt, Michael Cressy, Markus C Wahl, André Fiala, Matthias Selbach, Martin Schwärzel, Stephan J Sigrist |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
eLife, Vol 3 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
2050-084X |
| DOI: |
10.7554/eLife.03895 |
| Popis: |
CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal olfactory short- and intermediate-term memory. Drep-2 colocalized with metabotropic glutamate receptors (mGluRs). Chronic pharmacological stimulation of mGluRs compensated for drep-2 learning deficits, and drep-2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in effective mGluR signaling. In fact, Drosophila fragile X protein mutants, shown to benefit from attenuation of mGluR signaling, profited from the elimination of drep-2. Thus, Drep-2 is a novel regulatory synaptic factor, probably intersecting with metabotropic signaling and translational regulation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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