TEM8 in Oncogenesis: Protein Biology, Pre-Clinical Agents, and Clinical Rationale

Autor: Samuel A. Kareff, Virginia Corbett, Paul Hallenbeck, Aman Chauhan
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Cells, Vol 12, Iss 22, p 2623 (2023)
Druh dokumentu: article
ISSN: 12222623
2073-4409
DOI: 10.3390/cells12222623
Popis: The TEM8 protein represents an emerging biomarker in many solid tumor histologies. Given the various roles it plays in oncogenesis, including but not limited to angiogenesis, epithelial-to-mesenchymal transition, and cell migration, TEM8 has recently served and will continue to serve as the target of novel oncologic therapies. We review herein the role of TEM8 in oncogenesis. We review its normal function, highlight the additional roles it plays in the tumor microenvironment, and synthesize pre-clinical and clinical data currently available. We underline the protein’s prognostic and predictive abilities in various solid tumors by (1) highlighting its association with more aggressive disease biology and poor clinical outcomes and (2) assessing its associated clinical trial landscape. Finally, we offer future directions for clinical studies involving TEM8, including incorporating pre-clinical agents into clinical trials and combining previously tested oncologic therapies with currently available treatments, such as immunotherapy.
Databáze: Directory of Open Access Journals
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