Toxicity of commercial atrazine in rattus novergicus organs as a function of concentration: histopathological, ultrastructural and hematological evaluation
| Autor: | JOSÉ RIERA, ERICKA MATUS, LORENA MATUS, JAY MOLINO |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Anais da Academia Brasileira de Ciências, Vol 94, Iss 2 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1678-2690 0001-3765 |
| DOI: | 10.1590/0001-3765202220201125 |
| Popis: | Abstract The effect of commercial Atrazine (ATR) on Rattus Novergicus organs was determined for a concentration of cATRof 1, 3, 13, 30, and 50 ppb. ATR was dissolved in drinking water. The rats were allowed to drink from it ad libitum for an uninterrupted period of 28 days as established by the Office of Environmental Protection protocol under the number EPA OPPTS 870.3050. In the 28 days of the test, data on the behavior of the medicated animals was recorded before the extraction of sample tissues (heart, liver, spleen, brain, and testicles) for histological analysis. A direct correlation of cATRand organ damage was found. The study showed that even for the smallest doses (1ppb), commercial ATR produced several lesions in the studied animals. The rats showed hepatic periacinar necrosis with acute coagulation, hepatocyte lipidosis, severe portal lymphocytic inflammation, coronary periarteritis, and lymphocytic meningoencephalitis for high concentrations. In the male reproductive system, testicular degeneration with mild acute tubular necrosis was observed. |
| Databáze: | Directory of Open Access Journals |
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