Leptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats

Autor: Vojnović-Milutinović Danijela, Nikolić Marina, Dinić Jovana, Đorđević Ana, Veličković Nataša, Elaković Ivana, Matić Gordana, Nestorov Jelena
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Archives of Biological Sciences, Vol 66, Iss 2, Pp 829-839 (2014)
Druh dokumentu: article
ISSN: 0354-4664
1821-4339
DOI: 10.2298/ABS1402829M
Popis: Alterations in leptin and glucocorticoid signaling pathways in the hypothalamus of male and female rats subjected to a fructose-enriched diet were studied. The level of expression of the key components of the leptin signaling pathway (neuropeptide Y /NPY/ and suppressor of cytokine signaling 3 /SOCS3/), and the glucocorticoid signaling pathway (glucocorticoid receptor /GR/, 11β-hydroxysteroid dehydrogenase type 1 /11βHSD1/ and hexose-6-phosphate dehydrogenase /H6PDH/) did not differ between fructose-fed rats and control animals of both genders. However, in females, a fructose-enriched diet provoked increases in the adiposity index, plasma leptin and triglyceride concentrations, and displayed a tendency to decrease the leptin receptor (ObRb) protein and mRNA levels. In male rats, the fructose diet caused elevations in plasma non-esterified fatty acids and triglycerides, as well as in both plasma and hypothalamic leptin concentrations. Our results suggest that a fructose-enriched diet can induce hyperleptinemia in both female and male rats, but with a more pronounced effect on hypothalamic leptin sensitivity in females, probably contributing to the observed development of visceral adiposity. [Projekat Ministarstva nauke Republike Srbije, br. III41009]
Databáze: Directory of Open Access Journals