Zebrafish—A Suitable Model for Rapid Translation of Effective Therapies for Pediatric Cancers

Autor:	Debasish Roy, Bavani Subramaniam, Wai Chin Chong, Miriam Bornhorst, Roger J. Packer, Javad Nazarian
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	pediatric cancers zebrafish brain tumors drug toxicity targeted therapy animal model Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancers, Vol 16, Iss 7, p 1361 (2024)
Druh dokumentu:	article
ISSN:	2072-6694
DOI:	10.3390/cancers16071361
Popis:	Pediatric cancers are the leading cause of disease-related deaths in children and adolescents. Most of these tumors are difficult to treat and have poor overall survival. Concerns have also been raised about drug toxicity and long-term detrimental side effects of therapies. In this review, we discuss the advantages and unique attributes of zebrafish as pediatric cancer models and their importance in targeted drug discovery and toxicity assays. We have also placed a special focus on zebrafish models of pediatric brain cancers—the most common and difficult solid tumor to treat.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/729e1cfcb6b74d95b65479313fda326d Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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