Longitudinal Analysis of the Choriocapillaris Using Optical Coherence Tomography Angiography Reveals Subretinal Fluid as a Substantial Confounder in Patients with Acute Central Serous Chorioretinopathy

Autor: Michael Reich, Daniel Böhringer, Bertan Cakir, Felicitas Bucher, Moritz Daniel, Stefan Lang, Wolf Lagrèze, Hansjürgen Agostini, Clemens Lange
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Ophthalmology and Therapy, Vol 8, Iss 4, Pp 599-610 (2019)
Druh dokumentu: article
ISSN: 2193-8245
2193-6528
DOI: 10.1007/s40123-019-00218-9
Popis: Abstract Introduction To describe the influence of subretinal fluid (SRF) in analysis of the flow signal from the choriocapillaris (CC) via optical coherence tomography angiography (OCTA) in patients with acute central serous chorioretinopathy (CSC). Methods Observational, longitudinal, cross-sectional case–control study. Twenty-three eyes of 22 patients with acute CSC were compared with 20 eyes of 20 healthy controls. OCTA images (AngioPlex®, Zeiss) were recorded at baseline and follow-up examination and automatically quantified using an image-processing algorithm. Abnormal CC decorrelation signals (increased and decreased flow, IF and DF) were quantified using a custom image-processing algorithm. To analyze the spatial correlation between SRF and OCTA, CC signal heat-map images containing macular thickness information were used. Results Choriocapillaris flow alterations were significantly more pronounced at baseline than at follow-up examination in patients with acute CSC and resolving SRF (IF: p
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