| Autor: |
Kim Joo-Il, Park Sang-Wook, Lim Jhong-Jae, Sohn Se-Il, Shin Ji-Su, Park Sang Cheol, Jang Young Pyo, Chung Eun Kyoung, Lee Hong-Woo, Lee Kyung-Tae |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Acta Pharmaceutica, Vol 67, Iss 4, Pp 479-494 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1846-9558 |
| DOI: |
10.1515/acph-2017-0037 |
| Popis: |
In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl- or indomethacin- treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet. X-ray photographs in beagle dogs showed that IPAPFR was retained for > 2 h in the stomach. In the ethanol-induced gastric ulcer rat model, the gastric hemorrhagic lesion was improved more substantially with IPAP-FR compared to the non-floating control tablet. Based on these data, our data suggest that IPAP-FR has an improved therapeutic potential for the treatment of gastric ulcer. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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