3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry

Autor: D. O. Velez, B. Tsui, T. Goshia, C. L. Chute, A. Han, H. Carter, S. I. Fraley
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-017-01556-7
Popis: Extracellular matrix plays a central role in driving cancer development. Here the authors using an in vitro approach show that confining collagen architectures induce fast and persistent cell migration and the formation of multicellular network structures linked to vascular mimicry observed in tumours from patients.
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