Pathological Characteristics of Domestic Pigs Orally Infected with the Virus Strain Causing the First Reported African Swine Fever Outbreaks in Vietnam

Autor: Thi Thu Huyen Nguyen, Van Tam Nguyen, Phuong Nam Le, Nguyen Tuan Anh Mai, Van Hieu Dong, Tran Anh Dao Bui, Thi Lan Nguyen, Aruna Ambagala, Van Phan Le
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Pathogens, Vol 12, Iss 3, p 393 (2023)
Druh dokumentu: article
ISSN: 2076-0817
DOI: 10.3390/pathogens12030393
Popis: African swine fever (ASF) is currently Vietnam’s most economically significant swine disease. The first ASF outbreak in Vietnam was reported in February 2019. In this study, VNUA/HY/ASF1 strain isolated from the first ASF outbreak was used to infect 10 eight-week-old pigs orally with 103 HAD50 per animal. The pigs were observed daily for clinical signs, and whole blood samples were collected from each animal for viremia detection. Dead pigs were subjected to full post-mortem analyses. All 10 pigs displayed acute or subacute clinical signs and succumbed to the infection between 10 to 27 (19.8 ± 4.66) days post-inoculation (dpi). The onset of clinical signs started around 4–14 dpi. Viremia was observed in pigs from 6–16 dpi (11.2 ± 3.55). Enlarged, hyperemic, and hemorrhagic lymph nodes, enlarged spleen, pneumonia, and hydropericardium were observed at post-mortem examinations.
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