The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer

Autor:	Manel B. Hammouda, Amy E. Ford, Yuan Liu, Jennifer Y. Zhang
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	JNK skin inflammation keratinocytes BCC SCC melanoma Cytology QH573-671
Zdroj:	Cells, Vol 9, Iss 4, p 857 (2020)
Druh dokumentu:	article
ISSN:	2073-4409
DOI:	10.3390/cells9040857
Popis:	The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Our objective is to provide a review of JNK proteins and their upstream regulators and downstream effector molecules in common skin disorders, including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7274264321e54fcab5f855cafa601896 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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