A novel electrocardiographic index for the diagnosis of diastolic dysfunction.

Autor: Mehdi Namdar, Patric Biaggi, Barbara Stähli, Bernhard Bütler, Rubén Casado-Arroyo, Danilo Ricciardi, Moisés Rodríguez-Mañero, Jan Steffel, David Hürlimann, Christian Schmied, Carlo de Asmundis, Gian-Battista Chierchia, Andrea Sarkozy, Thomas F Lüscher, Rolf Jenni, Firat Duru, Walter J Paulus, Pedro Brugada
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: PLoS ONE, Vol 8, Iss 11, p e79152 (2013)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0079152
Popis: BackgroundAlthough the assessment of diastolic dysfunction (DD) is an integral part of routine cardiologic examinations, little is known about associated electrocardiographic (ECG) changes. Our aim was to investigate a potential role of ECG indices for the recognition of patients with DD.Methods and resultsECG parameters correlating with echocardiographic findings of DD were retrospectively assessed in a derivation group of 172 individuals (83 controls with normal diastolic function, 89 patients with DD) and their diagnostic performance was tested in a validation group of 50 controls and 50 patients. The patient group with a DD Grade 1 and 2 showed longer QTc (422 ± 24 ms and 434 ± 32 ms vs. 409 ± 25ms, pConclusionsA novel electrocardiographic index Tend-P/(PQxAge) demonstrates a high diagnostic accuracy for the diagnosis of DD and yields a substantial added value when combined with the LAESVI.
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