Detrimental consequences of micropolymers associated plasticizers on endocrinal disruption

Autor: Utsa Saha, Puja Kumari, Aishee Ghosh, Adrija Sinha, Snehasmita Jena, Apoorv Kirti, Abha Gupta, Anmol Choudhury, Faizan Zareen Simnani, Aditya Nandi, Rudra Narayan Sahoo, Shalini Kumari, Richa Mishra, Nagendra Kumar Kaushik, Deobrat Singh, Mrutyunjay Suar, Suresh K. Verma
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Materials Today Bio, Vol 27, Iss , Pp 101139- (2024)
Druh dokumentu: article
ISSN: 2590-0064
DOI: 10.1016/j.mtbio.2024.101139
Popis: The prevalence of polymer usage in everyday activities has emerged as a detriment to both human life and the environment. A large number of studies describe severe impacts of micropolymers (MP) and nanopolymers (NP) on various organ systems, including the endocrine system. Additionally, plasticizers utilized as additives have been identified as endocrine-disrupting chemicals (EDCs). MP/NP, along with associated plasticizers, affect principal signalling pathways of endocrine glands such as the pituitary, thyroid, adrenal, and gonads, thereby disrupting hormone function and metabolic processes crucial for maintaining homeostasis, fertility, neural development, and fetal growth. This review delves into the sources, distribution, and effects of micropolymers, nanopolymers, and associated plasticizers acting as EDCs. Furthermore, it provides a detailed review of the mechanisms underlying endocrine disruption in relation to different types of MP/NP.
Databáze: Directory of Open Access Journals