| Autor: |
Heloisa Rodrigues Pessoa, Lilia Zago, Cintia Chaves Curioni, Danielly C. Ferraz da Costa |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 98, Iss , Pp 105275- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2022.105275 |
| Popis: |
This systematic review summarized the role of olive oil intake in modulation of cancer risk biomarkers in healthy adults. A total of four randomized clinical trials with crossover design were included with intervention periods ranging from three to eight weeks, none of them at high risk of bias. meta-analysis was not performed because the studies were heterogeneous. Results showed that continuous olive oil intake was associated with the reduction of oxidized DNA bases, IL-8, TNF-α, and 8-OH deoxyguanosine, but did not affect ethene-DNA adducts. In summary, this study showed a potential role of olive oil intake by healthy individuals for prevention and repair of cancer-related DNA damage, through lower levels of markers of oxidative DNA damage and inflammation. High levels of these molecules are present and linked with tumor initiation and other carcinogenesis-related events. Therefore, olive oil is a promising agent for cancer risk reduction. To make this association robust, more intervention studies are needed, especially high-quality randomized controlled trials evaluating similar biomarkers over longer periods of time. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect