Repeated haploidentical allogeneic hematopoietic stem cell transplantation with TCR αβ/CD19 depletion in patient with primary myelofibrosis. Case report
| Autor: | Elmira I. Kolgaeva, Vera A. Vasilyeva, Larisa A. Kuzmina, Mikhail Yu. Drokov, Mariya V. Dovydenko, Zoya V. Konova, Dmitry I. Chebotarev, Alla M. Kovrigina, Denis V. Kamelskih, Tatyana V. Gaponova, Manana A. Sokolova, Irina N. Subortseva, Anait L. Melikyan, Mikhail A. Maschan, Elena N. Parovichnikova, Valerii G. Savchenko |
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| Jazyk: | ruština |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Терапевтический архив, Vol 93, Iss 7, Pp 805-810 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0040-3660 2309-5342 00403660 |
| DOI: | 10.26442/00403660.2021.07.200948 |
| Popis: | Indications of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with primary myelofibrosis are intermediate-2 and high-risk group of DIPSS (Dynamic International Prognostic Scoring System), beginning of the disease in childhood. The other adverse factors affect engraftment and survival after allo-HSCT, example partialy matched donor. But the result of allo-HSCT from matched related donors and result of allo-HSCT from haploidentical donors are comparable. The method for haploidentical hematopoietic stem cell transplantation is T-cell-depletion. This is clinical case of T-cell-depleted haploidentical hematopoietic stem cell transplantation in patient with primary myelofibrosis, the diagnosis was established in childhood. |
| Databáze: | Directory of Open Access Journals |
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