| Autor: |
Vinicius Pinto Costa Rocha, Bruna Aparecida Souza Machado, Breno Cardim Barreto, Helenita Costa Quadros, Antonio Márcio Santana Fernandes, Eduarda dos Santos Lima, Mariana Evangelista Bandeira, Cássio Santana Meira, Larissa Moraes dos Santos Fonseca, Jesse Erasmus, Amit Khandhar, Peter Berglund, Steve Reed, Roberto José da Silva Badaró, Milena Botelho Pereira Soares |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Heliyon, Vol 10, Iss 4, Pp e25539- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2405-8440 |
| DOI: |
10.1016/j.heliyon.2024.e25539 |
| Popis: |
Immune imprinting is now evident in COVID-19 vaccinated people. This phenomenon may impair the development of effective neutralizing antibodies against variants of concern (VoCs), mainly Omicron and its subvariants. Consequently, the boost doses with bivalent vaccines have not shown a significant gain of function regarding the neutralization of Omicron. The approach to design COVID-19 vaccines must be revised to improve the effectiveness against VoCs. Here, we took advantage of the self-amplifying characteristic of RepRNA and developed a polyvalent formulation composed of mRNA from five VoCs. LION/RepRNA Polyvalent induced neutralizing antibodies in mice previously immunized with LION/RepRNA D614G and reduced the imprinted phenotype associated with low neutralization capacity of Omicron B.1.1.529 pseudoviruses. The polyvalent vaccine can be a strategy to handle the low neutralization of Omicron VoC, despite booster doses with either monovalent or bivalent vaccines. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
