Interferon Gamma-induced Formation of Neopterin and Degradation of Tryptophan in Cerebrospinal Fluid of Children with Meningitis but Not with Febrile Convulsions
| Autor: | Zaknun D., Zaknun J., Unsinn K., Wächter H., Fuchs D. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: | |
| Zdroj: | Pteridines, Vol 5, Iss 3, Pp 102-106 (1994) |
| Druh dokumentu: | article |
| ISSN: | 0933-4807 2195-4720 |
| DOI: | 10.1515/pteridines.1994.5.3.102 |
| Popis: | Endogenously formed cytokines may play an important role in the development of meningitis, and it is necessary to understand in more detail inflammatory cascades involved in the disease process. We were interested to investigate biochemical changes which are inducible by interferon gamma. Therefore, we examined concentrations of neopterin, tryptophan, kynurenine and interferon gamma in cerebrospinal fluid (CSF) of 11 children with bacterial or viral meningitis and of 20 children with febrile convulsions, who suffered from viral or bacterial disease not involving the central nervous system. Concentrations of neopterin (mean ± S.D.: 43.9 ± 34.6 nmol/l) kyunrenine (0.41 ± 0.56 μmol/l) and interferon gamma (0.64 ± 0.81 U/ml) levels were higher in CSF of children with meningitis than in those with febrile convulsions (all p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|