| Autor: |
Ebrahim Miri‐Moghaddam, Fatemeh Sadat Mousavi, Hamid Salehiniya, Farzaneh Vafaeie, Hamid Abbaszadeh |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Health Science Reports, Vol 6, Iss 11, Pp n/a-n/a (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2398-8835 |
| DOI: |
10.1002/hsr2.1708 |
| Popis: |
Abstract Background and Aims Gene polymorphisms are responsible for at least part of the variation in caries susceptibility despite similar environmental factors. Genes involved in enamel formation like matrix metalloproteinase‐13 (MMP‐13) may participate in caries process. The aim was to investigate the association between MMP‐13 rs478927 polymorphism and caries susceptibility in 6‐years‐old children from Birjand, Iran. Methods Six‐years old children from Birjand, Iran, participated in this study. The total decayed, missing, and filled teeth were calculated and defined as caries index (CI). Based on this CI, two groups of high‐caries (case) and low‐caries (control) were taken into account. Saliva samples were collected and DNA was extracted. The allele and genotypes of MMP‐13 rs478927 polymorphism were determined by tetra‐primer amplification refractory mutation system‐polymerase chain reaction (T‐ARMS‐PCR) method. p Value was significant if p 0.05). There wasn't any significant association between genotype distribution of MMP‐13 rs478927 polymorphism and CI groups (p = 0.924). This polymorphism was associated with increased caries susceptibility under all genetic models but this effect was not significant (p > 0.05). Conclusion The MMP‐13 rs478927 gene polymorphism was not significantly associated with dental caries susceptibility in Birjandi children with mixed dentition. It is recommended to conduct studies on children of different dentitions to better understand the role of this polymorphism on caries susceptibility in primary and permanent teeth of children. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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