ANP32E induces tumorigenesis of triple‐negative breast cancer cells by upregulating E2F1

Autor: Zhenchong Xiong, Liping Ye, He Zhenyu, Fengyan Li, Yahui Xiong, Chuyong Lin, Xianqiu Wu, Guangzheng Deng, Wei Shi, Libing Song, Zhongyu Yuan, Xi Wang
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Molecular Oncology, Vol 12, Iss 6, Pp 896-912 (2018)
Druh dokumentu: article
ISSN: 1878-0261
1574-7891
DOI: 10.1002/1878-0261.12202
Popis: Triple‐negative breast cancer (TNBC) lacks expression of estrogen receptor (ER), progesterone receptor, and the HER2 receptor; it is highly proliferative and becomes the deadliest forms of breast cancer. Effective prognostic methods and therapeutic targets for TNBC are required to improve patient outcomes. Here, we report that acidic nuclear phosphoprotein 32 family member E (ANP32E), which promotes cell proliferation in mammalian development, is highly expressed in TNBC cells compared to other types of breast cancer. High expression of ANP32E correlates significantly with worse overall survival (OS; P
Databáze: Directory of Open Access Journals
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