FEATURES OF PLATELET HEMOSTASIS IN PATIENTS WITH VARIOUS SENSITIVITY TO ANTIPLATELET THERAPY IN STABLE ANGINA PECTORIS AFTER PLANNED PERCUTANEOUS CORONARY INTERVENTION
| Autor: | Pronko T. P., Snezhitskiy V. A., Makarova E. A., Avseenko A. A., Kharitonenko Т. V. |
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| Jazyk: | Belarusian<br />English<br />Russian |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, Vol 15, Iss 5, Pp 504-509 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2221-8785 2413-0109 |
| DOI: | 10.25298/2221-8785-2017-15-5-504-509 |
| Popis: | Background. One of the significant problems of using double antiplatelet therapy (DATT) in patients with ischemic heart disease is the development of resistance to acetylsalicylic acid (ASA) and to clopidogrel. Purpose of the study. Evaluation of the features of platelet hemostasis in patients with different sensitivity to DATT with stable angina pectoris (SAP) who have undergone scheduled percutaneous coronary intervention (PCI). Material and methods. Sixty patients with stable angina pectoris who underwent planned PCI and received DATT were examined. A blood test and a study of the morphometric parameters of platelets: MPV, PDW, PCT, P-LCR were performed by means of cytoflowing method on the automatic hemo-analyzer Sysmex XS-500i, Japan. Platelet aggregation was evaluated on an impedance 5-channel Multiplateaggregometer (VerumDiagnostica GmbH, Germany) with several aggregation inducers. Results. 45% of patients with insufficient response to DAPT were detected – SG2. TRAP-test was 90.62 ± 18.37 U in SG1, 110.7 ± 19.83 U in SG2, p |
| Databáze: | Directory of Open Access Journals |
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