Association of CYP1A2 and GST gene variants with asthma in cases presenting with allergic chronic rhinosinusitis

Autor:	Madhavi Jangala, Santoshi Kumari Manche, Madhu Mohan Katika, Raja Meghanadh Koralla, Jyothy Akka
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Allergy Asthma Chronic rhinosinusitis Cytochrome P450 1A2 Glutathione-S-transferase Haplotype Medicine (General) R5-920 Genetics QH426-470
Zdroj:	Egyptian Journal of Medical Human Genetics, Vol 24, Iss 1, Pp 1-13 (2023)
Druh dokumentu:	article
ISSN:	2090-2441
DOI:	10.1186/s43042-023-00397-y
Popis:	Abstract Background Inter-individual differences in regulation and activity of xenobiotic metabolizing enzymes (XMEs) CYP1A and GST might cause distinct susceptibility to chronic rhinosinusitis (CRS) phenotypes that need to be explored. Therefore, the present study aimed to evaluate the role and risk of CYP1A and GST gene variants in allergic CRS subjects with and without asthma. A total of 224 allergic CRS cases with asthma, 252 allergic CRS cases without asthma, and 350 healthy control subjects were subjected to genetic analysis. Gene variants of cytochrome P450 (CYP1A1 T3801 rs4646903, A2455G rs1048943, C2453A rs1799814 and CYP1A2 G3858A rs2069514, T739G rs2069526, C163A rs762551) and glutathione S-transferase P (GSTP1 A313G rs1605 & C341T rs1799811) were investigated by polymerase chain reaction-restriction fragment length polymorphism and GSTM1null, and GSTT1null by multiplex PCR methods. Results TG genotype of CYP1A2 rs2069526 (OR 1.73, 95% CI 1.20–2.50, p
Databáze:	Directory of Open Access Journals
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