Effects of Exercise on Serum Inflammatory Markers and NF-kb, COX-2 mRNA Expression in Prostate of BPH-Induced Mice
| Autor: | Eun-Jung Yoon, Se-Hwan Park, Eun-Mi Lim |
|---|---|
| Jazyk: | korejština |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | 운동과학, Vol 30, Iss 4, Pp 510-516 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1226-1726 2384-0544 |
| DOI: | 10.15857/ksep.2021.00521 |
| Popis: | PURPOSE Benign prostatic hypertrophy (BPH) is a common finding in older men and a frequent cause of lower urinary tract symptoms. The efficacy of exercise in the management of BPH-related inflammation is not fully understood. Thus, we investigated the effects of exercise on inflammatory markers in a mouse model of BPH. METHODS A total of 36 male C57BL/6 mice were divided into three groups; CON (sham control, n=12), BPH-CON (received testosterone propionate [TP] control, n=12), and BPH-EXE (TP+aerobic exercise group, n=12). For BPH induction, mice were castrated and testosterone propionate (3 mg/kg/day) was administered by subcutaneous injection. The exercise group was forced to run on a treadmill for 30 minutes 3 times per week for 12 weeks. RESULTS The BPH-CON group showed significantly increased blood pro-inflammatory cytokines such as interleukin-6, -1β, and TNF-α compared with CON (p |
| Databáze: | Directory of Open Access Journals |
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