Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase

Autor: Alec Fraser, Maria L. Sokolova, Arina V. Drobysheva, Julia V. Gordeeva, Sergei Borukhov, John Jumper, Konstantin V. Severinov, Petr G. Leiman
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-31214-6
Popis: Promoter recognition is a critical step in the initiation of transcription of DNA to RNA. Here, the authors describe a novel mechanism by which a phage-encoded RNA polymerase recognizes viral promoters containing deoxyuridines instead of thymidines.
Databáze: Directory of Open Access Journals